Mariel Hemingway is attempting the lift the “curse” of self-destruction that plagues her gifted and beautiful family. The patriarchal figure, Ernest Hemingway, whose golden words still seduce the masses, is at once a symbol of robust life, and of alcoholism, depression, and suicide. There is growing research that indicates these traits: alcoholism and mental illness are often linked to genetics. Of course, a toxic or emotionally unstable family life can lead to mood problems regardless of the genetics – whether it’s nature or nurture or a poison soup of both, madness tends to run in families. In Running From Crazy, a Barbara Kopple directed documentary film that came out last year and is now getting a run on Oprah’s OWN Network, Ernest Hemingway’s granddaughter Mariel Hemingway confronts her family’s decades-long curse of despair in an attempt to understand it and break free of it.